Some of the Premier League's biggest stars are set to miss this weekend's fixtures due to the scheduling of CONMEBOL's World Cup Qualifiers.
South American nations are being enforced to squeeze three matches into the October international break as a result of a backlog of fixtures.
Postponed games during the coronavirus pandemic are having to be played at an alarmingly quick rate with the 2022 World Cup just over a year away.
But that means key players from the likes of Liverpool, Manchester City and Manchester United are set to miss crucial clashes in the Premier League this weekend.
Daily Star Sport reveals eight South American stars who are set to miss matches over the coming days.
The Liverpool shot-stopper has played every minute for the Reds in the Premier League and Champions League so far this season.
But Alisson will be missing from the dugout for the trip to Vicarage Road as Brazil are in action just 35 hours before Jurgen Klopp's side are due to face Watford.
Liverpool are in action at 12:30pm on Saturday with the Seleaco's match against Uruguay kicking off at 1:30am UK time on Friday morning.
The Reds had asked to move their game back to a later start time of 7:45pm on Saturday but Watford rejected the proposal on the basis that it would mess with supporters who had already made plans.
2. Edinson Cavani
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The Uruguay striker will also be involved in the World Cup qualification match on Friday morning and so will be unable to travel back in time for United's next match.
The Red Devils take on Leicester City and are suffering a defensive crisis ahead of the match at Old Trafford.
Harry Maguire and Raphael Varane are both out injured with Ole Gunnar Solskjaer even considering a shock return for Phil Jones who is back in full training.
Cavani should be back fit and ready to play in Man Utd's Champions League fixture on Wednesday evening against Atalanta.
Like his compatriot Alisson, the Manchester City 'keeper is yet to miss a Premier League match for Pep Guardiola's side so far this season.
But Ederson is likely to have to watch from the bench with the Liverpool shot-stopper preferred between the sticks by manager Tite.
As a result, the 28-year-old will miss the Citizen's home match against Burnley in the Premier League with Zack Steffen expected to deputise.
Having started the last two matches for his country, the Brazilian is likely to play an instrumental part in the Seleaco's match against Uruguay on Friday morning.
Therefore, Jurgen Klopp will have to suffice without two of his big-name players with the Reds also without 'keeper Alisson.
It could have been worse for the German gaffer though. Mercilessly Roberto Firmino was not selected for the October internationals and is available for selection against Watford.
Firmino is Brazil's second top goalscorer in the World Cup qualification matches behind PSG's Neymar.
Fabinho has played the full 90 minutes for the past five Premier League matches though and will be a big miss for the Reds in the centre of midfield.
5. Gabriel Jesus
Yet to score for Brazil so far in qualification, Jesus has led the line for the Seleaco in the past two matches in the absence of Firmino and Everton forward Richarlison.
The 24-year-old has averaged a goal every three matches for City this season and will be keen to break his duct against Uruguay.
Blessed with a star-studded squad Pep Guardiola's side should have enough to dispatch a Burnley side who are yet to pick up a win so. far in the Premier League this season.
But they'll have to do it without Ederson and Jesus with the Citizens in action just 37-and-a-half hours after Brazil's World Cup Qualifier in Manaus.
6. Emi Martinez
The Aston Villa 'keeper is in action for Argentina against Peru at 12:30am Friday morning UK time.
Having started every qualifier this year, La Albiceleste manager Lionel Scaloni is likely to stick with Martinez in goal as Argentina look to narrow the gap on table leaders and fierce rivals Brazil.
Villa host fellow midlands side Wolves just 38-and-a-half hours after the kick-off time in Buenos Aires.
Dean Smith opted for Jed Steer when Martinez was caught up with international commitments in September.
The tricky Leeds United winger has also been selected by Tite as part of Brazil's October international squad and made his debut from the bench in their last match against Venezuela.
The 24-year-old assisted 2 goals and won a penalty after being subbed on at half-time and is reportedly set for a full debut on Friday morning.
Leeds face Southampton on the south coast just 37-and-a-half hours after the Seleaco's clash with Uruguay.
8. Thiago Silva
The Brazil captain was no surprise inclusion, receiving his 100th cap with a substitute appearance against Colombia.
Yet his call-up does mean he will miss Chelsea's first-ever London derby against Brentford in the top-flight.
The Bees were promoted to the Premier League for the first time in their history last season.
Brazil's World Cup Qualifier kicks off 41 hours before the Blues fixture at the Brentford Community Stadium.
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